NHS Warns Against Omeprazole: Understanding the Risks and Benefits

The UK’s National Health Service (NHS) has issued a warning against the prolonged unsupervised use of omeprazole, one of the country’s most prescribed medications. With over 73 million prescriptions dispensed in England between 2022 and 2023, it’s crucial to understand the potential risks associated with this proton pump inhibitor (PPI).

What is Omeprazole Used For?

Omeprazole is commonly prescribed to manage conditions like:

• Indigestion: Relief from heartburn and acid reflux
• Healing stomach ulcers: Treatment of stomach ulcers and prevention of further ulcers
• Gastro-oesophageal reflux disease (GORD/GERD): Management of acid reflux and heartburn
• Acid-related inflammation of the food pipe: Treatment of inflammation caused by stomach acid

Risks Associated with Long-Term Use

The NHS warns against prolonged unsupervised use of omeprazole due to the increased risk of ¹:

• Clostridioides difficile (C. diff) infection: A bacterial infection that can cause diarrhoea, abdominal pain, and fever
• Gut health problems: Disruption of the balance of gut bacteria, potentially leading to infections

Who is at Risk?

Certain individuals are more susceptible to the risks associated with omeprazole, including:

• Older adults: Increased risk of C. diff infection and other complications
• Hospital patients: Higher risk of infection due to exposure to contaminated surfaces and weakened immune systems
• People with weakened immune systems: Increased vulnerability to infections

Safe Use of Omeprazole

To minimize risks, patients should:

• Follow dosage instructions carefully: Take omeprazole as directed by your doctor or pharmacist
• Avoid prolonged self-medication: Consult your doctor if symptoms persist or worsen
• Discuss alternative treatments: Explore other options with your doctor if symptoms persist
• Seek medical advice promptly: If new symptoms appear, especially diarrhoea, fever, or severe abdominal pain

Common Side Effects

While generally well-tolerated, omeprazole can cause side effects like ¹:

• Headaches
• Stomach pain
• Nausea or vomiting
• Constipation or diarrhoea
• Excessive flatulence

By understanding the benefits and risks of omeprazole and following NHS guidelines, patients can use this medication safely and effectively to manage their acid-related conditions